The pontiff, who will later fly out to the Philippines, arrangements to commend outside masses amid his excursion.
It is the first ecclesiastical visit to Sri Lanka since the end of a four-decade common war in 2009.
The nation's new president, chose a week ago, has guaranteed an end to becoming suppression of religious minorities.
The Pope's outing, which comes five months after a voyage through South Korea, is being seen as an endeavor to win new devotees in Asia and to shore up backing for the area's a great many Catholics.
Before leaving on Monday, he said the visit reflected his "pastoral concern" for the populace of the district, as per the Reuters news organization.
Huge swarms of individuals lined the lanes of the Sri Lankan capital, Colombo, on Tuesday to welcome his motorcade.
The Pope is quick to bring a message of compromise to Sri Lanka, and help mend the injuries of a long and biting common war.
He lands to meet the new Sri Lankan president, who out of the blue won the snap race after the island's disliked President Rajapaksa surrendered annihilation.
Just under 10% of the populace are Catholic - yet they incorporate both the lion's share Sinhalese and the minority Tamils, offering Pope Francis the opportunity to head out to the "Our Lady of Madhu" place of worship, which is venerated by both, to bring his expressions of peace.
Around 70% of Sri Lankans are Buddhist, with 13% Hindus and 10% Muslims.
Amid the last ecclesiastical visit 20 years back, Pope John Paul II was boycotted by Buddhist pioneers.
At the same time on this visit, the Pope is relied upon to hold a multi-confidence petition to God meeting which ought to incorporate moderate Buddhist agents.
Be that as it may, Buddhist fundamentalism has become as an energy in Sri Lanka since the last ecclesiastical visit, with some pursuing a vicious fight against Muslims on the island.
Pope Francis needs to energize the neighborhood church in Sri Lanka to look for accomplices in peace, so that all religions can stand united against any further brutality or intimidation by religious fanatics.
In the Philippines coordinators are expecting one of the greatest swarms ever for an ecclesiastical visit when Pope Francis conducts an outside mass in the capital Manila.
Church authorities say his visit to the archipelago country will concentrate on "kindness and sympathy" taking after a lethal 2013 tropical storm, reports the AFP news organization.
It is a period of critical change in Sri Lanka, where Maithripala Sirisena took office as president on Friday.
He finished the decade-long run of previous President Mahinda Rajapaksa, a period which commentators said had been damaged by expanding debasement and dictatorship.
